What was the temperature profile of step 1 in batch 48Q?21 Aug 01:20
Step 1 temperature profile (batch 48Q):
Step 1 is the phosphate-ester preparation. The recorded profile has two phases:
1. Charge and heat: Vicaspin LUB 1010 (R225100845) Bu-EO-PO, HV-62.3 / MW-900 was charged to the RBF and heated to 50 °C.
2. Digestion: P2O5 was then slowly added under N2 atmosphere, and the mixture was digested for 3 hrs at 70–75 °C.
The record's structured temperature field for the step is 58–75 °C, total step time 5 hrs. End-of-step result: cooled to RT, AV-52.52; remarks "Mono-24.44 / Di-51.76/ Free acid-0.24".
Note: there is a minor internal discrepancy — the procedure text says "heated to 50 deg C" then "digested ... at 70-75 deg C", while the extracted step-level temperature range is recorded as "58–75 °C". Both come from the same ELN page.
Step 1 is the phosphate-ester preparation. The recorded profile has two phases:
1. Charge and heat: Vicaspin LUB 1010 (R225100845) Bu-EO-PO, HV-62.3 / MW-900 was charged to the RBF and heated to 50 °C.
2. Digestion: P2O5 was then slowly added under N2 atmosphere, and the mixture was digested for 3 hrs at 70–75 °C.
The record's structured temperature field for the step is 58–75 °C, total step time 5 hrs. End-of-step result: cooled to RT, AV-52.52; remarks "Mono-24.44 / Di-51.76/ Free acid-0.24".
Note: there is a minor internal discrepancy — the procedure text says "heated to 50 deg C" then "digested ... at 70-75 deg C", while the extracted step-level temperature range is recorded as "58–75 °C". Both come from the same ELN page.
Sources
confidence: high